Author's response to reviews Title: Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts Authors:
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چکیده
Johanna M Tuomela ([email protected]) Tove J Grönroos ([email protected]) Maija P Valta ([email protected]) Jouko A Sandholm ([email protected]) Aleksi Schrey ([email protected]) Jani A Seppänen ([email protected]) Päivi Marjamäki ([email protected]) Sarita Forsback ([email protected]) Ilpo Kinnunen ([email protected]) Olof Solin ([email protected]) Heikki Minn ([email protected]) Pirkko L Härkönen ([email protected])
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Author's response to reviews Title: The synthetic peptide P111-136 derived from the C-terminal domain of heparin affin regulatory peptide inhibits tumour growth of prostate cancer PC-3 cells Authors:
Title: The synthetic peptide P111-136 derived from the C-terminal domain of heparin affin regulatory peptide inhibits tumour growth of prostate cancer PC-3 cells
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22 Estrogens contribute to the development and growth of the prostate and are implicated in prostate 23 tumorigenesis. In their target tissues, estrogens mediate their effects via estrogen receptor alpha 24 (ERa) and beta (ERb). Hyperplasia and decreased differentiation of epithelial cells in the prostate 25 have been reported in ERb knockout (BERKO) mice. We studied here the effect of ERb defi...
متن کاملA long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers
Fibroblast growth factor-8b (FGF8b) affects the epithelial/stromal compartments of steroid hormone-regulated tumors by exerting an autocrine activity on cancer cells and a paracrine pro-angiogenic function, thus contributing to tumor progression. The FGF8b/FGF receptor (FGFR) system may therefore represent a target for the treatment of steroid hormone-regulated tumors. The soluble pattern recog...
متن کاملLong pentraxin-3 inhibits FGF8b-dependent angiogenesis and growth of steroid hormone-regulated tumors.
Fibroblast growth factor-8b (FGF8b) exerts nonredundant autocrine/paracrine functions in steroid hormone-regulated tumors. Previous observations had shown that the soluble pattern recognition receptor long pentraxin-3 (PTX3) is a natural selective antagonist for a restricted number of FGF family members, inhibiting FGF2 but not FGF1 and FGF4 activity. Here, we assessed the capacity of PTX3 to a...
متن کاملTherapeutic Discovery Long Pentraxin-3 Inhibits FGF8b-Dependent Angiogenesis and Growth of Steroid Hormone–Regulated Tumors
Fibroblast growth factor-8b (FGF8b) exerts nonredundant autocrine/paracrine functions in steroid hormone–regulated tumors. Previous observations had shown that the soluble pattern recognition receptor long pentraxin-3 (PTX3) is a natural selective antagonist for a restricted number of FGF family members, inhibiting FGF2 but not FGF1 and FGF4 activity. Here, we assessed the capacity of PTX3 to a...
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تاریخ انتشار 2010